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Tuesday, January 31, 2012

Human teeth: Biomaterials and Titanium implants

Arza Abdul Aleem Baig

Department of Biomedical Engineering, Mehran University of Engineering and Technology, Jamshoro, Sindh, Pakistan.

The development of biomaterials is not a new area of science, having existed for around half a century. The study of biomaterials is called biomaterial sciences. Biomaterial sciences encompass elements of medicine, biology, chemical/chemistry, tissue engineering and material sciences. Biomaterial sciences involve customization of materials for medical applications. Examples of these applications include artificial skin, vascular and cardiovascular implants and devices, bone graft substitutes, prosthetic devices, dental materials etc.

Recently, materials (biomaterial) used in medicine have made enormous impact on the repair and replacement of injured and diseased part of the human body and the field is growing at a rapid pace. While the implementation of some of the biomedical materials may be for medical reasons such as the replacement of diseased tissues required to extend life expectancies, other reasons may include purely artistic one including breast implants. This increasing demand arises from an ageing population with higher quality of life expectations. The biomaterial scientists are producing new and improved implantable materials and techniques to meet this demand.

Full article at: http://www.dentalnewspk.com/News/Dental-Viewz/Human-teeth-Biomaterials-and-Titanium-implants.html

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Disclaimer

Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Friday, January 27, 2012

Counterfeit Colgate Toothpaste Found in U.S. Could Contain Poison

Counterfeit tubes of Colgate brand toothpaste, possibly containing Diethylene Glycol, a poisonous chemical used in antifreeze, have been found in at least four states. The toothpaste was reportedly being sold from small dollar and discount stores in New York, New Jersey, Pennsylvania and Maryland.

These 5 oz. tubes of counterfeit toothpaste appear to be regular Colgate toothpaste, but a closer look at the label shows several misspellings along with the words, "Manufactured in South Africa." The Colgate Palmolive Company states that Diethylene Glycol is not used in any Colgate toothpaste in the United States or anywhere else in the world and Colgate does not import toothpaste from South Africa into America.

The Colgate Company is working closely with the United States Food and Drug Administration (FDA) and taking steps to ensure that none of their accounts have the counterfeit toothpaste on their shelves.

Full article found at: http://dentistry.about.com/od/researchandstudie1/a/colgatecount.htm

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Disclaimer

Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Tuesday, January 24, 2012

Blast of gas that could replace dentist's drill and make fillings stronger

A new ‘gas-firing’ device may offer a pain-free alternative to the dentist’s drill — and could make fillings even more hard-wearing.

The device, which resembles an electric toothbrush, cleans out cavities in rotten teeth in only 30 seconds, according to new research.

It works by generating high-energy gas and liquid particles to kill bacteria and blast out the decayed pulp of the tooth.


Read more: http://www.dailymail.co.uk/health/article-2090764/Blast-gas-replace-dentists-drill-make-fillings-stronger.html#ixzz1kOhZxZ8a

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ACES is the world's leader in providing live webcast dental continuing education

Disclaimer

Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Monday, January 23, 2012

Fluoridated toothpaste fast falling out of favour

FLUORIDE is a naturally occurring element that prevents tooth decay when ingested systemically or applied topically. Researchers believe that there are several mechanisms by which fluoride achieves its anti-carious effect. It reduces the solubility of enamel in acid by converting hydroxyapatite into less soluble fluoroapatie; it may exert an influence directly on dental plaque, reducing the ability of plaque organisms to produce acid; and it promotes the remineralization of tooth enamel in areas that have been decalcified by acids.

Most likely, fluoride works by a combination of these effects. But the remineralization effect of fluoride is of prime importance, because it results in a reversal of the early caries process, and gives rise to enamel more resistant to decay.

In 1914, fluoride was added to toothpaste, but became more widespread when it was recommended by the American Dental Association (ADA) in the 1950s. The Centers for Disease Control and Prevention has proclaimed community water fluoridation as one of the 10 great public health achievements of the 20th Century. Most States in the USA have fluoride in their drinking water. However, relatively recently, there has been some reconsideration among the scientific community about this material.


For full article: http://www.guyanachronicleonline.com/site/index.php?option=com_content&view=article&id=38142:fluoridated-toothpaste-fast-falling-out-of-favour-&catid=20:dentist-speaks&Itemid=19


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ACES is the world's leader in providing live webcast dental continuing education

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Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Friday, January 20, 2012

Dentists Could Screen 20 Million Americans For Chronic Physical Illnesses

Nearly 20 million Americans annually visit a dentist but not a general healthcare provider, according to an NYU study published in the American Journal of Public Health.

The study, conducted by a nursing-dental research team at NYU, is the first of its kind to determine the proportion of Americans who are seen annually by a dentist but not by a general healthcare provider.

This finding suggests dentists can play a crucial role as health care practitioners in the front-line defense of identifying systemic disease which would otherwise go undetected in a significant portion of the population, say the researchers.

For full article: http://www.medicalnewstoday.com/releases/239315.php

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Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Thursday, January 19, 2012

How Cavity-Causing Microbes Invade Heart

Scientists have discovered the tool that bacteria normally found in our mouths use to invade heart tissue, causing a dangerous and sometimes lethal infection of the heart known as endocarditis. The work raises the possibility of creating a screening tool -- perhaps a swab of the cheek, or a spit test -- to gauge a dental patient's vulnerability to the condition.

The identification of the protein that allows Streptococcus mutans to gain a foothold in heart tissue is reported in the June issue of Infection and Immunity by microbiologists at the University of Rochester Medical Center.

S. mutans is a bacterium best known for causing cavities. The bacteria reside in dental plaque -- an architecturally sophisticated goo composed of an elaborate molecular matrix created by S. mutans that allows the bacteria to inhabit and thrive in our oral cavity. There, they churn out acid that erodes our teeth.

The above story is reprinted from materials provided by University of Rochester Medical Center.

For Full article: http://www.sciencedaily.com/releases/2011/06/110627095650.htm

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Disclaimer

Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Wednesday, January 18, 2012

Teeth of Dead Bodies can Reveal Their Identity?

Researchers from the University of Granada have said that a person's dental patterns could be as reliable an identity proof for dead bodies as DNA.

Forensic police uses DNA testing to reveal the identity of dead bodies.

The researchers came to the conclusion after analysing the dental patterns of more than 3,000 people.

"There is sufficient dental diversity between people to enable a scientifically-based human identification method to be developed for forensic purposes," said Stella Martin de las Heras, lead author of the study.

Read more: Teeth of Dead Bodies can Reveal Their Identity? | MedIndia http://www.medindia.net/news/Teeth-of-Dead-Bodies-can-Reveal-Their-Identity-70795-1.htm#ixzz1jqBSPNhf

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ACES is the world's leader in providing live webcast dental continuing education

Disclaimer

Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Tuesday, January 17, 2012

New Device Set to Combat Fear of the Dentist's Drill

An innovative device which cancels out the noise of the dental drill could spell the end of people's anxiety about trips to the dentist, according to experts at King's College London, Brunel University and London South Bank University, who pioneered the invention.

It is widely known that the sound of the dental drill is the prime cause of anxiety about dental treatment, and some patients avoid trips to the dentist because of it. This new device could help address people's fears and encourage them to seek the oral healthcare treatment they need.

The prototype device works in a similar way to noise-cancelling headphones but is designed to deal with the very high pitch of the dental drill. Patients would simply unplug their headphones, plug the device into their MP3 player or mobile phone, and then plug the headphones into the device, allowing them to listen to their own music while completely blocking out the unpleasant sound of the drill and suction equipment. The patient can still hear the dentist and other members of the dental team speaking to them but other unwanted sounds are filtered out by the device.

For full article: http://www.sciencedaily.com/releases/2011/01/110110053040.htm

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Disclaimer

Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Monday, January 16, 2012

Male Cigarette Smokers More Likely to Need Root Canals

According to a recent report from the American Dental Association, males that smoke cigarettes are almost twice as likely to need root canals based on news reports about an extensive study listed to appear in the Journal of Dental Research in April 2006. 

For full article: http://dentistry.about.com/od/toothmouthconditions/a/malesmokers.htm

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Disclaimer

Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Friday, January 13, 2012

Bee Propolis - Reduces Tooth Sensitivity & Cavities?

By Gene Bruno, MS, MHS: Dean of Huntington College of Heath Sciences. 

Antibacterial/Antifungal Activity

In-vitro (i.e., “test tube”) research has demonstrated that propolis has significant antibacterial activity, and also helps to reduce oxidation potential.[1] Other research has also verified that the growth of bacteria (particularly Gram-positive bacteria) is inhibited by propolis.[2] [3] [4] In addition to its antibacterial properties, propolis has also been found to have antifungal effects against Candida albicans.[5] Furthermore, research has shown that propolis has specific antibacterial activity against several strains isolated from patients with infections in their upper respiratory tracts.[6]

Dental Research
Some interesting dental studies have also been conducted on the value of propolis, including its antibacterial properties. In one study, propolis was found to inhibit certain enzymes and bacteria that are chief culprits in the formation of dental caries (cavities).[7] Other research on propolis has also demonstrated a similar antibacterial effect, including a reduction of bacteria in saliva.[8]

Another dental-related value of propolis is its desensitizing properties for teeth. In one study, propolis was administered to 26 women over a period of four weeks. The women were tested for teeth sensitivity by two methods: 1) cold air stimuli, and 2) subjective reporting of pain. Eighty five percent of the subjects in this study reported that they were highly satisfied; the propolis had significant desensitizing effects on their sensitive teeth.[9]

For full article: http://www.bing.com/search?q=propolis&form=HPNTDF&pc=HPNTDF&src=IE-SearchBox

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Disclaimer

Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Wednesday, January 11, 2012

Gum Disease Can Increase the Time It Takes to Become Pregnant

ScienceDaily (July 5, 2011) — Professor Roger Hart told the annual meeting of the European Society of Human Reproduction and Embryology that the negative effect of gum disease on conception was of the same order of magnitude as the effect of obesity.

Periodontal (gum) disease is a chronic, infectious and inflammatory disease of the gums and supporting tissues. It is caused by the normal bacteria that exist in everyone's mouths, which, if unchecked, can create inflammation around the tooth; the gum starts to pull away from the tooth, creating spaces (periodontal pockets) that become infected. The inflammation sets off a cascade of tissue-destructive events that can pass into the circulation. As a result, periodontal disease has been associated with heart disease, type 2 diabetes, respiratory and kidney disease, and problems in pregnancy such as miscarriage and premature birth. Around 10% of the population is believed to have severe periodontal disease. Regular brushing and flossing of teeth is the best way of preventing it.

For full article: http://www.sciencedaily.com/releases/2011/07/110705071548.htm

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Disclaimer

Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Tuesday, January 10, 2012

Blood Thinners and Dental Care

Antiplatelet and Anticoagulant Agents and Dental Procedures

An increasing number of dental patients are taking “blood thinner” medications for various medical conditions. These drugs interfere with the body’s normal clotting (stopping blood flow) mechanism. There are two main processes by which the body normally forms a blood clot at the site of tissue injury. The first involves small blood cells called platelets which clump together at the wound to form a mechanical plug. This plug slows the flow of blood through the vessel and forms a matrix for the next phase of coagulation. During coagulation chemicals in the blood interact with each other to fill in the spaces between the platelets, stabilize the clot, and make it more solid until the process stops the bleeding.

Antiplatelet agents such as aspirin, Ticlid (ticlopidine), and Plavix (clopidogrel) target the first phase of clot formation by preventing platelets from sticking together and adhering to blood vessels. These agents do this by creating permanent changes in the platelets which last throughout the lifetime of the platelet (7-10 days). These effects can only be countered as the body produces new platelets that have not been exposed to the drug.

For full article: http://www.aaom.com/patients/blood-thinners-and-dental-care/

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ACES is the world's leader in providing live webcast dental continuing education

Disclaimer

Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Monday, January 9, 2012

Nanocrystals make dentures shine

The hardest substance in the human body is moved by its strongest muscles: When we heartily bite into an apple or a schnitzel, enormous strengths are working on the surface of our teeth. "What the natural tooth enamel has to endure also goes for dentures, inlays or bridges", glass chemist Prof. Dr. Christian Rüssel of the Friedrich Schiller University Jena (Germany) says. After all, these are worn as much as healthy teeth. Ceramic materials used so far are not very suitable for bridges, as their strengths are mostly not high enough. Now Prof. Rüssel and his colleagues of the Otto-Schott-Institute for Glass Chemistry succeeded in producing a new kind of glass ceramic with a nanocrystalline structure, which seems to be well suited to be used in dentistry due to their high strength and its optical characteristics.
The glass chemists of Jena University recently published their research results in the online-edition of the science magazine Journal of Biomedical Materials Research veröffentlicht ("Colorless and high strength MgO/Al2O3/SiO2 glass–ceramic dental material using zirconia as nucleating agent").

For full article: http://www.nanowerk.com/news/newsid=23874.php

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Disclaimer

Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Sunday, January 8, 2012

Dried Licorice Root Fights the Bacteria That Cause Tooth Decay and Gum Disease

Scientists are reporting identification of two substances in licorice -- used extensively in Chinese traditional medicine -- that kill the major bacteria responsible for tooth decay and gum disease, the leading causes of tooth loss in children and adults. In a study in ACS' Journal of Natural Products, they say that these substances could have a role in treating and preventing tooth decay and gum disease.


Stefan Gafner and colleagues explain that the dried root of the licorice plant is a common treatment in Chinese traditional medicine, especially as a way to enhance the activity of other herbal ingredients or as a flavoring. Despite the popularity of licorice candy in the U.S., licorice root has been replaced in domestic candy with anise oil, which has a similar flavor. Traditional medical practitioners use dried licorice root to treat various ailments, such as respiratory and digestive problems, but few modern scientific studies address whether licorice really works. (Consumers should check with their health care provider before taking licorice root because it can have undesirable effects and interactions with prescription drugs.) To test whether the sweet root could combat the bacteria that cause gum disease and cavities, the researchers took a closer look at various substances in licorice.

For full article: http://www.sciencedaily.com/releases/2012/01/120104115106.htm

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Disclaimer

Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Saturday, January 7, 2012

Premature Children Have Smaller Teeth

The size of teeth in premature children is smaller than that of children who were full-term, according to a study by the Faculty of Odontology at Malmö University in Sweden.

Our knowledge about premature children, and their physical and mental development as they grow up, is constantly growing. In recent years several studies of children's dental health have been published by researchers at the Faculty of Odontology in Malmö. Liselotte Paulsson-Björnsson, a specialist in orthodontics, has studied 80 children born before week 33 of pregnancy.

"We have examined how their teeth are developing and, among other things, we've looked at their bites. We've also checked their need for orthodontic adjustments and found that it is greater than in the control group, children born at full term," she says.

For full article: http://www.sciencedaily.com/releases/2011/10/111027082747.htm

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Disclaimer

Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Friday, January 6, 2012

Unhealthy Gums Increase Risk Of Premature Delivery

Gum disease can do more than affecting just your gums. It can increase the risk of diabetes, cardiovascular disease and premature delivery. The following is the conclusion arrived at a conference on periodontal disease, held at New York.

Participants at the conference highlighted the accumulating evidence regarding increased risk of serious illness in association with gum disease. They further reflected the need for a collaborative work between both dentists and medical health professionals.


Read more: Unhealthy Gums Increase Risk Of Premature Delivery | MedIndia http://www.medindia.net/news/view_news_main.asp?x=8099#ixzz1ihBajqHi

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ACES is the world's leader in providing live webcast dental continuing education

Disclaimer

Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Thursday, January 5, 2012

FDA Issues Final Regulation on Dental Amalgam

The U.S. Food and Drug Administration today issued a final regulation classifying dental amalgam and its component parts – elemental mercury and a powder alloy—used in dental fillings. While elemental mercury has been associated with adverse health effects at high exposures, the levels released by dental amalgam fillings are not high enough to cause harm in patients.

The regulation classifies dental amalgam into Class II (moderate risk). By classifying a device into Class II, the FDA can impose special controls (in addition to general controls such as good manufacturing practices that apply to all medical devices regardless of risk) to provide reasonable assurance of the safety and effectiveness of the device.

The special controls that the FDA is imposing on dental amalgam are contained in a guidance document that contains, among other things, recommendations on performance testing, device composition, and labeling statements.

Specifically, the FDA recommended that the product labeling include:

  • A warning against the use of dental amalgam in patients with mercury allergy;
  • A warning that dental professionals use adequate ventilation when handling dental amalgam;
  • A statement discussing the scientific evidence on the benefits and risk of dental amalgam, including the risks of inhaled mercury vapor. The statement will help dentists and patients make informed decisions about the use of dental amalgam.

For full article: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm173992.htm

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ACES is the world's leader in providing live webcast dental continuing education

Disclaimer

Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Wednesday, January 4, 2012

DNA Vaccines Show Promise in Preventing Dental Caries

In a report on a preclinical investigation titled "Flagellin Enhances Saliva Ig A Response and Protection of Anti-caries DNA Vaccine," lead author Wei Shi, Wuhan Institute of Virology, Chinese Academy of Sciences, and his team of researchers demonstrate that anti-caries DNA vaccines, including pGJA-P/VAX, are promising for preventing dental caries. However, challenges remain because of the low immunogenicity of DNA vaccines.

In this study, Shi and team used recombinant flagellin protein derived from Salmonella as mucosal adjuvant for anti-caries DNA vaccine (pGJA-P/VAX) and analyzed the effects of Salmonella protein on the serum surface protein immunoglobulin G and saliva surface protein immunoglobulin A antibody responses, the colonization of Streptococcus mutans (S. mutans) on rodent teeth, and the formation of caries lesions. The results showed that Salmonella promoted the production of surface protein immunoglobulin G in serum and secretory immunoglobulin A in saliva of animals by intranasal immunization with pGJA-P/VAX plus Salmonella.
This study is published in the Journal of Dental Research, the official publication of the International and American Associations for Dental Research (IADR/AADR).

For full article: http://www.sciencedaily.com/releases/2011/10/111025143526.htm

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ACES is the world's leader in providing live webcast dental continuing education

Disclaimer

Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Tuesday, January 3, 2012

Dentist 411 - False Invoices from ADA Association

Dental offices have been receiving misleading invoices from an organization calling itself ADA Association. This is NOT the ADA (American Dental Association). Please be very careful as this is a misleading fraud. Beware of this scam.

Teeth Crowded in Seniors, as Jaws Shrink

The size of our jaws decreases with age. This is shown in a unique study from the Faculty of Dentistry at Malmö University that followed a cohort of dentists throughout their adult lives.

The unique study started in 1949. Plaster molds were made of the jaws of dental students, who were then in their twenties. Ten years later the procedure was repeated, and in 1989, forty years after the first molds, a final round was performed. On that occasion the researchers were in touch with 18 of the original 30 participants.

"We found that over these forty years there was less and less room for teeth in the jaw," says Lars Bondemark, professor of orthodontics, who analyzed the material together with his colleague Maria Nilner, professor of clinical bite physiology at the College of Dentistry, Malmö University.

Full article at: http://www.sciencedaily.com/releases/2011/10/111031114809.htm

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ACES is the world's leader in providing live webcast dental continuing education

Disclaimer

Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Monday, January 2, 2012

Web-based live continuing education will dominate 2012

2012 should be the year that web-based continuing education in dentistry really moves forward. ACES has been broadcasting live, seminars over the internet for six years and each year the number of participants has grown.

Six years ago, alomost every licensing agency considered live webcasts to be the same as a take home, self-study course. Due to ACES efforts over the past six years this has all changed. Boards now understand the difference between a static or pre-recorded self-study course and a live, real-time, interactive webinar.

Live, web-based education is taking hold in college and high school levels as well. The world is moving towards internet-based content. Our ability to interact and educate via the internet is now at a point that the participants enjoy the same level of learning as the local based seminars of the past.

As more people become familiar with the convenience and quality of live, web-based continuing education the number of people seeking this type of delivery system continues to grow. I predict that by the end of this decade, more people will be obtaining their live course requirements over the internet than in desk & table seminars.

ACES will continue to expand our offerings for dental professionals for online, real-time continuing education. We currently offer 18 diffent topics and teach over 20 days each month. Recently we have added morning & weekend webinars.

Check ACES out at www.aces4ce.com

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ACES is the world's leader in providing live webcast dental continuing education

Disclaimer

Content on this blog are for informational purposes only, is neither intended to and does not establish a standard of care, and is not a substitute for professional judgment, advice, diagnosis, or treatment. ACES is not responsible for information on external websites linked to this website.

Sunday, January 1, 2012

Bad dental health can lead to pneumonia

The Dental Health Foundation has warned that poor oral hygiene could cause the respiratory infection after research found a link between bacteria in the mouth and the lung disease.

Dr Samit Joshi of Yale University School of Medicine found changes in bacteria in the mouth preceded the development of pneumonia.
He concluded that this process “suggests that changes in oral bacteria play a role in the risk for developing pneumonia".
Pneumonia is thought to affect more than 620,000 people in the UK and claims the lives of around five per cent of those who contract the disease.
Although further research is required to determine the exact relationship between oral health and pneumonia, it is not the first time the two diseases have been linked.

For full article: http://www.telegraph.co.uk/health/healthnews/8979191/Bad-dental-health-can-lead-to-pneumonia-Yale-study-suggests.html