In this study, Shi and team used recombinant flagellin protein derived from Salmonella as mucosal adjuvant for anti-caries DNA vaccine (pGJA-P/VAX) and analyzed the effects of Salmonella protein on the serum surface protein immunoglobulin G and saliva surface protein immunoglobulin A antibody responses, the colonization of Streptococcus mutans (S. mutans) on rodent teeth, and the formation of caries lesions. The results showed that Salmonella promoted the production of surface protein immunoglobulin G in serum and secretory immunoglobulin A in saliva of animals by intranasal immunization with pGJA-P/VAX plus Salmonella.
For full article: http://www.sciencedaily.com/releases/2011/10/111025143526.htm
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